Geometry-driven immunomodulation in 3D-printed bioceramics: Negative curvature promotes macrophage M2 polarization via Ras-MAPK/HIF-1α signaling for vascularized osteogenesis

The geometric features of bioactive scaffolds are biophysical cues regulate cell fate, but their immunomodulatory potential in bone regeneration is yet to be determined. Growing evidence suggests that surface curvature is a potent regulator of cellular behaviours and osteogenesis. Therefore, we quan...

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Bibliographic Details

Main Authors:	Qiji Lu, Yudi Kuang, Jingjing Diao, Jiaqian Zheng, Naru Zhao, Chang Du, Yingjun Wang
Format:	Artigo
Language:	Inglês
Published:	KeAi Communications Co., Ltd. 2026-06-01
Series:	Bioactive Materials
Subjects:	Gaussian curvature High-throughput screening Macrophage polarization Immunomodulatory biomaterials Bone regeneration
Online Access:	http://www.sciencedirect.com/science/article/pii/S2452199X26000010
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