Optimized Southern blotting for enhanced and precise detection of transgenes in CHO cells from transposon-based expression systems

The genetic stability of recombinant CHO cell lines producing therapeutic proteins is critical for ensuring consistent quality in biopharma­ceutical products. Southern blotting remains the gold standard for evaluating transgene integrity and stability in these cell lines. In the biopharmaceutical in...

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Hlavní autoři:	Hyo-Young Jeong, Caitlyn Devine, Bor-Ruei Lin, Zhenqiu Huang, Guanghua Li, Lin Zhang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis Group 2026-12-01
Edice:	BioTechniques
Témata:	Chinese hamster ovary (CHO) cell transposon genetic stability Southern blot transgene integration sites
On-line přístup:	https://www.tandfonline.com/doi/10.1080/07366205.2026.2621051
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