Mesothelioma location influences the tumour microenvironment and immune checkpoint therapy response in preclinical models

Abstract Mesothelioma is a cancer derived from mesothelial cells, most commonly arising from the pleura or the peritoneum. Immune checkpoint therapy (ICT) has shown survival benefit for pleural mesothelioma, but little is known about the response in peritoneal mesothelioma. Most preclinical mesothel...

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Principais autores:	M. Lizeth Orozco Morales, Sally M. Lansley, Wee Loong Chin, Caitlin M. Tilsed, Nicola Principe, Connull Leslie, Breana J. Vitali, Francois X. Rwandamuriye, Emma de Jong, Joel Kidman, Rachael M. Zemek, Catherine A. Rinaldi, Timo Lassmann, Anthony Bosco, Y. C. Gary Lee, Richard A. Lake, Jonathan Chee, W. Joost Lesterhuis
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-02-01
coleção:	Scientific Reports
Assuntos:	Mesothelioma Anatomical location Tumour microenvironment Immune checkpoint therapy
Acesso em linha:	https://doi.org/10.1038/s41598-026-41431-4
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