Development of the first geldanamycin-based HSP90 degraders
Despite the early clinical promise, adverse events such as acquired resistance and dose-limiting toxicities have barred the widespread use of HSP90 inhibitors as anticancer drugs. A new approach involving proteolysis-targeting chimeras (PROTACs) to degrade the protein instead of inhibiting it may ov...
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| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Chemistry |
| Assuntos: | |
| Acceso en liña: | https://www.frontiersin.org/articles/10.3389/fchem.2023.1219883/full |
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