Tyrosine-Modification of Polypropylenimine (PPI) and Polyethylenimine (PEI) Strongly Improves Efficacy of siRNA-Mediated Gene Knockdown

The delivery of small interfering RNAs (siRNA) is an efficient method for gene silencing through the induction of RNA interference (RNAi). It critically relies, however, on efficient vehicles for siRNA formulation, for transfection in vitro as well as for their potential use in vivo. While polyethyl...

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Hauptverfasser:	Sandra Noske, Michael Karimov, Achim Aigner, Alexander Ewe
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2020-09-01
Schriftenreihe:	Nanomaterials
Schlagworte:	polypropylenimine dendrimers polyethylenimines tyrosine-modified polypropylene-imines tyrosine-modified polyethlyenimines PPI-Y siRNA transfection
Online-Zugang:	https://www.mdpi.com/2079-4991/10/9/1809
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