Targeting serine/glycine metabolism to attenuate IFN-γ- and IL-22-driven inflammation and hyperproliferation in psoriasis

Abstract Psoriasis is a chronic skin disease characterized by keratinocyte hyperproliferation and inflammation, largely driven by the cytokines IL-22 and interferon (IFN)-γ. These cytokines activate the signal transducer and activator of transcription (STAT) 3 and STAT1 molecular pathways, leading t...

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Detalhes bibliográficos

Principais autores:	Laura Mercurio, Valentina Di Francesco, Simone Sergio, Martina Morelli, Claudia Scarponi, Stefania Madonna, Sabatino Pallotta, Mara Mancini, Angela Cappello, Eleonora Candi, Cristina Albanesi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2026-05-01
Colecção:	Cell Death Discovery
Acesso em linha:	https://doi.org/10.1038/s41420-026-03138-3
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