Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity

Abstract Mitochondrial fusion/fission dynamics plays a fundamental role in neuroprotection; however, there is still a severe lack of therapeutic targets for this biological process. Here, we found that the naturally derived small molecule echinacoside (ECH) significantly promotes mitochondrial fusio...

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Автори:	Ke-Wu Zeng, Jing-Kang Wang, Li-Chao Wang, Qiang Guo, Ting-Ting Liu, Fu-Jiang Wang, Na Feng, Xiao-Wen Zhang, Li-Xi Liao, Mei-Mei Zhao, Dan Liu, Yong Jiang, Pengfei Tu
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Nature Publishing Group 2021-02-01
Серія:	Signal Transduction and Targeted Therapy
Онлайн доступ:	https://doi.org/10.1038/s41392-020-00447-6
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