Epigenetic and metabolic rewiring in metastatic pheochromocytomas and paragangliomas driven by SDHB mutations

Abstract Pheochromocytomas and paragangliomas (PPGLs) with SDHB mutations frequently develop metastases, but the molecular mechanisms driving this progression remain unclear. Here we show that SDHB-mutant metastatic PPGLs display an amplified hypermethylation signature, particularly in genes involve...

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Bibliografski detalji

Glavni autori:	Tamara Cubiella, Juan José Alba-Linares, Jaime San-Juan-Guardado, Alvaro Suarez-Priede, Nerea Gómez-Suárez, Maria Tous, Irina Bancos, Carles Villabona, Teresa Serrano, Isabel Tena, Maribel Del Olmo, Lluis Forga, Nuria Valdés, Mario F. Fraga, María-Dolores Chiara
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2026-01-01
Serija:	Communications Biology
Online pristup:	https://doi.org/10.1038/s42003-026-09543-9
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