Functional profiling of somatostatin receptors identifies somatostatin receptor subtype 2 as a vulnerability in Succinate Dehydrogenase SDHB-deficient pheochromocytomas and paragangliomas

Abstract Pheochromocytomas and Paragangliomas (PPGL) are rare neuroendocrine tumors with favorable prognosis, although a significant subset (20–25%) progress to metastasis, worsening patient prognosis. For metastatic cases, pharmacological interventions become essential, yet most tumors show poor re...

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Egile Nagusiak:	Víctor García-Vioque, Sergio Pedraza-Arevalo, María Trinidad Moreno-Montilla, Esther Rivero-Cortés, Ricardo Blázquez-Encinas, Federica Mangili, Ester Arroba, Aura D. Herrera-Martínez, Michael D. Culler, María Ángeles Gálvez-Moreno, Anne Barlier, Luisa María Botella, Mercedes Robledo, Justo P. Castaño, Alejandro Ibáñez-Costa
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Springer 2026-04-01
Saila:	Molecular Biomedicine
Gaiak:	Pheochromocytoma Paraganglioma Somatostatin Somatostatin Receptor 2 SDHB
Sarrera elektronikoa:	https://doi.org/10.1186/s43556-026-00440-5
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