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Single-cell transcriptomic profiling and machine learning identify S-nitrosylation-associated LAMC2 as a key prognostic driver in pancreatic cancer

Abstract Background Pancreatic cancer (PC) remains one of the deadliest malignancies worldwide, characterized by late diagnosis, limited therapeutic options, and dismal prognosis. Post-translational modifications (PTMs) are increasingly recognized as key regulators of tumor biology, yet the role of...

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Principais autores: Chenchen Yang, Hengfa Ge, Yunfan Yin, Jialing Zhang, Aifeng Gong
פורמט: Artigo
שפה:Inglês
יצא לאור: Springer 2025-12-01
סדרה:Discover Oncology
נושאים:
Pancreatic cancer
S-nitrosylation
Single-cell RNA sequencing
Machine learning
LAMC2
גישה מקוונת:https://doi.org/10.1007/s12672-025-04324-y
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