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HIF-1α-mediated LAMC1 overexpression is an unfavorable predictor of prognosis for glioma patients: evidence from pan-cancer analysis and validation experiments

Abstract Background Laminin subunit gamma-1 (LAMC1) is a major extracellular matrix molecule involved in the tumor microenvironment. Knowledge of the biological features and clinical relevance of LAMC1 in cancers remains limited. Methods We conducted comprehensive bioinformatics analysis of LAMC1 ge...

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Principais autores: Jianrong Bai, Yangyang Zhao, Kaijia Shi, Yonghao Fan, Yanping Ha, Yan Chen, Botao Luo, Yanda Lu, Wei Jie, Zhihua Shen
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-04-01
coleção:Journal of Translational Medicine
Assuntos:
LAMC1
HIF-1α
Pan-cancer
Gliomas
Prognosis
Acesso em linha:https://doi.org/10.1186/s12967-024-05218-3
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