Managing intrathecal administration of nusinersen in adolescents and adults with 5q-spinal muscular atrophy and previous spinal surgery

ABSTRACT Background: Spinal muscular atrophy (SMA) is a neurodegenerative disease of lower motor neurons associated with frequent occurrence of spinal deformity. Nusinersen is an antisense oligonucleotide that increases SMN protein level and is administrated by frequent intrathecal lumbar injection...

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Príomhchruthaitheoirí:	Rodrigo de Holanda Mendonça, Hermann dos Santos Fernandes, Rafael Barbéro Schimmelpfeng Pinto, Ciro Matsui Júnior, Graziela Jorge Polido, André Macedo Serafim da Silva, Luis Fernando Grossklauss, Umbertina Conti Reed, Edmar Zanoteli
Formáid:	Artigo
Teanga:	Inglês
Foilsithe / Cruthaithe:	Thieme Revinter Publicações
Sraith:	Arquivos de Neuro-Psiquiatria
Ábhair:	Muscular Atrophy, Spinal Antisense Oligonucleotide Spinal Puncture Survival of Motor Neuron 1 Protein Motor Neuron Disease
Rochtain ar líne:	http://www.scielo.br/pdf/anp/v79n2/1678-4227-anp-79-02-0127.pdf
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Managing intrathecal administration of nusinersen in adolescents and adults with 5q-spinal muscular atrophy and previous spinal surgery

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