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Managing intrathecal administration of nusinersen in adolescents and adults with 5q-spinal muscular atrophy and previous spinal surgery

ABSTRACT Background: Spinal muscular atrophy (SMA) is a neurodegenerative disease of lower motor neurons associated with frequent occurrence of spinal deformity. Nusinersen is an antisense oligonucleotide that increases SMN protein level and is administrated by frequent intrathecal lumbar injection...

Deskribapen osoa

Gorde:
Egile Nagusiak: Rodrigo de Holanda Mendonça, Hermann dos Santos Fernandes, Rafael Barbéro Schimmelpfeng Pinto, Ciro Matsui Júnior, Graziela Jorge Polido, André Macedo Serafim da Silva, Luis Fernando Grossklauss, Umbertina Conti Reed, Edmar Zanoteli
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Thieme Revinter Publicações
Saila:Arquivos de Neuro-Psiquiatria
Gaiak:
Muscular Atrophy, Spinal
Antisense Oligonucleotide
Spinal Puncture
Survival of Motor Neuron 1 Protein
Motor Neuron Disease
Sarrera elektronikoa:http://www.scielo.br/pdf/anp/v79n2/1678-4227-anp-79-02-0127.pdf
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