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Cross-species validation of a human age-related hearing loss candidate KLHDC7B as essential for mammalian hearing

Abstract Although age-related hearing loss (ARHL) is the most common sensory loss in older adults, underlying mechanisms remain unclear. Recent genome-wide association studies (GWAS) linked variation in several genes with ARHL risk, including KLHDC7B, a gene of unknown function not previously linked...

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Principais autores: Alexandra M. Kaufman, Benjamin Silver, Roberto A. Donnianni, Carlos Aguilar, Lingzi Niu, Daniel Johnson, Anwen Bullen, Alma Corona, Benjamin J. van Soldt, Nilay Vora, Gervasio Batista, Luz Cortes-Burgos, Jacqueline Copeland, Elika Fallah, Norman Zhang, Marina Lehmkuhl, Sarah Cancelarich, Kara Campos, Daniela Di Battista Miani, Jaylen Mumphrey, Susan D. Croll, Johnathon R. Walls, Mary Germino, Michael R. Bowl, Meghan C. Drummond, Sally J. Dawson
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2025-12-01
coleção:Communications Biology
Acesso em linha:https://doi.org/10.1038/s42003-025-09349-1
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