B-cell tumor development in Tet2-deficient mice
Abstract: The TET2 gene encodes an α-ketoglutarate–dependent dioxygenase able to oxidize 5-methylcytosine into 5-hydroxymethylcytosine, which is a step toward active DNA demethylation. TET2 is frequently mutated in myeloid malignancies but also in B- and T-cell malignancies. TET2 somatic mutations a...
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| Hauptverfasser: | , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Elsevier
2018-03-01
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| Schriftenreihe: | Blood Advances |
| Online-Zugang: | http://www.sciencedirect.com/science/article/pii/S247395292031065X |
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