IGF1R signalling is a guardian of self-tolerance restricting autoantibody production

ObjectiveInsulin-like growth factor 1 receptor (IGF1R) acts at the crossroad between immunity and cancer, being an attractive therapeutic target in these areas. IGF1R is broadly expressed by antigen-presenting cells (APC). Using mice immunised with the methylated albumin from bovine serum (BSA-immun...

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Principais autores:	Malin C. Erlandsson, Seval Erdogan, Caroline Wasén, Karin M. E. Andersson, Sofia T. Silfverswärd, Rille Pullerits, Mats Bemark, Maria I. Bokarewa
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2022-08-01
Serija:	Frontiers in Immunology
Teme:	rheumatoid arthritis FoxO1 IGF1R marginal zone autoantibodies
Online dostop:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.958206/full
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