Short hydrophobic loop motifs in BRICHOS domains determine chaperone activity against amorphous protein aggregation but not against amyloid formation

Abstract ATP-independent molecular chaperones are important for maintaining cellular fitness but the molecular determinants for preventing aggregation of partly unfolded protein substrates remain unclear, particularly regarding assembly state and basis for substrate recognition. The BRICHOS domain c...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Gefei Chen, Axel Leppert, Helen Poska, Harriet E. Nilsson, Carlos Piedrafita Alvira, Xueying Zhong, Philip Koeck, Caroline Jegerschöld, Axel Abelein, Hans Hebert, Jan Johansson
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2023-05-01
Schriftenreihe:	Communications Biology
Online-Zugang:	https://doi.org/10.1038/s42003-023-04883-2
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