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Age-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in mice.

When 5-lipoxygenase (5-LO) is inhibited, roughly half of the CNS effect of the prototypic endocannabinoid anandamide (AEA) is lost. Therefore, we decided to investigate whether inhibiting this enzyme would influence physiological functions classically described as being under control of the endocann...

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Autori principali: Luciana M Leo, Suellen Almeida-Corrêa, Claudio A Canetti, Olavo B Amaral, Fernando A Bozza, Fabricio A Pamplona
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2014-01-01
Serie:PLoS ONE
Accesso online:https://doi.org/10.1371/journal.pone.0085009
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