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Phylogenomics-guided discovery of a novel conserved cassette of short linear motifs in BubR1 essential for the spindle checkpoint

The spindle assembly checkpoint (SAC) maintains genomic integrity by preventing progression of mitotic cell division until all chromosomes are stably attached to spindle microtubules. The SAC critically relies on the paralogues Bub1 and BubR1/Mad3, which integrate kinetochore–spindle attachment stat...

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Principais autores: Eelco Tromer, Debora Bade, Berend Snel, Geert J. P. L. Kops
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society 2016-01-01
Serier:Open Biology
Fag:
kinetochore
mitosis
evolutionary genomics
short linear motif
spindle checkpoint
Online adgang:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.160315
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