Gene-body DNA methylation of ONECUT2 predicts its expression and prostate cancer aggressiveness in needle biopsies

Abstract Background ONECUT2 is a lineage plasticity driver and therapeutic target in aggressive prostate cancer (PCa). This study investigated whether ONECUT2 gene-body DNA methylation regulates its expression and assessed its potential as a biomarker in clinical specimens. Methods We analyzed assoc...

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Opis bibliograficzny

Główni autorzy:	Yohei Sekino, Hong-Tao Li, Masatomo Kaneko, Yuta Inoue, Lorenzo Storino Ramacciotti, Rongying Lu, Zhenzhong Deng, Xinyi Zhou, Michelle Mingxue Song, Aditya Desai, Mingda Jin, Wei Guo, Xiaojing Yang, Jeffrey Bhasin, Nobuyuki Hinata, Michael R. Freeman, Inderbir Gill, Manju Aron, Steven Yong Cen, Andre Luis Abreu, Gangning Liang
Format:	Artigo
Język:	Inglês
Wydane:	BMC 2026-01-01
Seria:	Biomarker Research
Hasła przedmiotowe:	ONECUT2 Prostate cancer Gene-body DNA methylation Gene expression Aggressive prostate cancer
Dostęp online:	https://doi.org/10.1186/s40364-026-00890-7
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