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Neutral sphingomyelinase-induced ceramide triggers germinal vesicle breakdown and oxidant-dependent apoptosis in Xenopus laevis oocytes

Ceramide regulates many cellular processes, including cell growth, differentiation, and apoptosis. Although the effects of exogenous bacterial neutral sphingomyelinase (SMase) in Xenopus laevis oocytes have been investigated, its microinjection into oocytes has not been reported previously. Thus, we...

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Principais autores: Olga Coll, Albert Morales, José C. Fernández-Checa, Carmen Garcia-Ruiz
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2007-09-01
coleção:Journal of Lipid Research
Assuntos:
mitochondria
reactive oxygen species
cell death
reduced glutathione
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0022227520424800
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