Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes

Summary: MHC-E regulates NK cells by displaying MHC class Ia signal peptides (VL9) to NKG2A:CD94 receptors. MHC-E can also present sequence-diverse, lower-affinity, pathogen-derived peptides to T cell receptors (TCRs) on CD8+ T cells. To understand these affinity differences, human MHC-E (HLA-E)-VL9...

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Principais autores:	Lucy C. Walters, Daniel Rozbesky, Karl Harlos, Max Quastel, Hong Sun, Sebastian Springer, Robert P. Rambo, Fiyaz Mohammed, E. Yvonne Jones, Andrew J. McMichael, Geraldine M. Gillespie
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2022-06-01
Serija:	Cell Reports
Teme:	CP: Immunology
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2211124722007410
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