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Are Wnt/β-Catenin and PI3K/AKT/mTORC1 Distinct Pathways in Colorectal Cancer?Summary

Wnt/β-catenin and phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin complex 1 (PI3K/AKT/mTORC1) pathways both are critically involved in colorectal cancer (CRC) development, although they are implicated in the modulation of distinct oncogenic mechanisms. In homeostatic and...

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Principais autores: Anna Prossomariti, Giulia Piazzi, Chiara Alquati, Luigi Ricciardiello
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020-01-01
Serier:Cellular and Molecular Gastroenterology and Hepatology
Fag:
Wnt/β-Catenin
PI3K/AKT/mTORC1
Colorectal Cancer
Crosstalk
Resistance
Online adgang:http://www.sciencedirect.com/science/article/pii/S2352345X20300515
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