Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy.
Fasting reduces glucose levels and protects mice against chemotoxicity, yet drugs that promote hyperglycemia are widely used in cancer treatment. Here, we show that dexamethasone (Dexa) and rapamycin (Rapa), commonly administered to cancer patients, elevate glucose and sensitize cardiomyocytes and m...
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| Principais autores: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science (PLoS)
2017-03-01
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| coleção: | PLoS Biology |
| Acesso em linha: | http://europepmc.org/articles/PMC5373519?pdf=render |
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