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Acute mechanical injury of the human intervertebral disc: link to degeneration and pain

Excessive mechanical loading or acute trauma to intervertebral discs (IVDs) is thought to contribute to degeneration and pain. However, the exact mechanisms by which mechanical injury initiates and promotes degeneration remain unclear. This study investigates biochemical changes and extracellular ma...

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Principais autores: B Alkhatib, DH Rosenzweig, E Krock, PJ Roughley, L Beckman, T Steffen, MH Weber, JA Ouellet, L Haglund
Format: Artigo
Sprog:Inglês
Udgivet: Forum Multimedia Publishing LLC 2014-09-01
Serier:European Cells & Materials
Fag:
Intervertebral disc
mechanical injury
inflammation
extracellular matrix
degeneration
nerve growth factor
Online adgang:http://www.ecmjournal.org/journal/papers/vol028/pdf/v028a08.pdf
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