Hyper-physiologic mechanical cues, as an osteoarthritis disease-relevant environmental perturbation, cause a critical shift in set points of methylation at transcriptionally active CpG sites in neo-cartilage organoids

Abstract Background Osteoarthritis (OA) is a complex, age-related multifactorial degenerative disease of diarthrodial joints marked by impaired mobility, joint stiffness, pain, and a significant decrease in quality of life. Among other risk factors, such as genetics and age, hyper-physiological mech...

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Bibliografiska uppgifter

Huvudupphov:	Niek G. C. Bloks, Amanda Dicks, Zainab Harissa, Rob G. H. H. Nelissen, Ghazaleh Hajmousa, Yolande F. M. Ramos, Rodrigo Coutinho de Almeida, Farshid Guilak, Ingrid Meulenbelt
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	BMC 2024-05-01
Serie:	Clinical Epigenetics
Ämnen:	Osteoarthritis DNA methylation Chondrocytes Mechanical loading Environmental stressors
Länkar:	https://doi.org/10.1186/s13148-024-01676-0
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