Hyper-physiologic mechanical cues, as an osteoarthritis disease-relevant environmental perturbation, cause a critical shift in set points of methylation at transcriptionally active CpG sites in neo-cartilage organoids
Abstract Background Osteoarthritis (OA) is a complex, age-related multifactorial degenerative disease of diarthrodial joints marked by impaired mobility, joint stiffness, pain, and a significant decrease in quality of life. Among other risk factors, such as genetics and age, hyper-physiological mech...
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| Principais autores: | , , , , , , , , |
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| 格式: | Artigo |
| 语言: | Inglês |
| 出版: |
BMC
2024-05-01
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| 丛编: | Clinical Epigenetics |
| 主题: | |
| 在线阅读: | https://doi.org/10.1186/s13148-024-01676-0 |
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