Glycolysis‐Histone Lactylation Crosstalk Drives TXNIP‐NLRP3‐Mediated PANoptosome Assembly and PANoptosis Activation Underlying Diabetic Retinopathy Pathogenesis

ABSTRACT Diabetic retinopathy (DR), a major cause of vision loss in adults, involves aberrant metabolism and inflammation. This study investigated the interplay between glycolysis, histone lactylation, and PANoptosis in DR using human retinal pigment epithelial (RPE) cells under high glucose and dia...

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Principais autores:	Xiaoting Xi, Qianbo Chen, Jia Ma, Xuewei Wang, Yuxin Zhang, Qiuxia Xiong, Xiaolei Liu, Yuan Xia, Yan Li
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Wiley 2025-09-01
סדרה:	MedComm
נושאים:	diabetic retinopathy glycolysis histone lactylation PANoptosis thioredoxin interacting protein
גישה מקוונת:	https://doi.org/10.1002/mco2.70351
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!