Glycolysis‐Histone Lactylation Crosstalk Drives TXNIP‐NLRP3‐Mediated PANoptosome Assembly and PANoptosis Activation Underlying Diabetic Retinopathy Pathogenesis

ABSTRACT Diabetic retinopathy (DR), a major cause of vision loss in adults, involves aberrant metabolism and inflammation. This study investigated the interplay between glycolysis, histone lactylation, and PANoptosis in DR using human retinal pigment epithelial (RPE) cells under high glucose and dia...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Xiaoting Xi, Qianbo Chen, Jia Ma, Xuewei Wang, Yuxin Zhang, Qiuxia Xiong, Xiaolei Liu, Yuan Xia, Yan Li
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Wiley 2025-09-01
Цуврал:	MedComm
Нөхцлүүд:	diabetic retinopathy glycolysis histone lactylation PANoptosis thioredoxin interacting protein
Онлайн хандалт:	https://doi.org/10.1002/mco2.70351
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!