Dual Blockade of Lactate/GPR81 and PD-1/PD-L1 Pathways Enhances the Anti-Tumor Effects of Metformin

Metformin is a widely used antidiabetic drug for cancer prevention and treatment. However, the overproduction of lactic acid and its inefficiency in cancer therapy limit its application. Here, we demonstrate the synergistic effects of the lactate/GPR81 blockade (3-hydroxy-butyrate, 3-OBA) and metfor...

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Detalles Bibliográficos

Principais autores:	Shaomeng Chen, Xiuman Zhou, Xin Yang, Wanqiong Li, Shuzhen Li, Zheng Hu, Chen Ling, Ranran Shi, Juan Liu, Guanyu Chen, Nazi Song, Xianxing Jiang, Xinghua Sui, Yanfeng Gao
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2021-09-01
Series:	Biomolecules
Assuntos:	metformin GPR81 lactate cancer immunotherapy PD-1/PD-L1 blockade
Acceso en liña:	https://www.mdpi.com/2218-273X/11/9/1373
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