Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS–mitochondrial fission–mitophagy axis

Despite recent progress in non‐small‐cell lung cancer (NSCLC) treatment, treatment outcomes remain poor, mainly because of treatment resistance or toxicity. Erastin is a ferroptosis inducer that has shown promising cytotoxic effects in various types of cancers, including NSCLC. Celastrol is a triter...

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Autors principals:	Ming Liu, Yumei Fan, Danyu Li, Bihui Han, Yanxiu Meng, Fei Chen, Tianchan Liu, Zhiyuan Song, Yu Han, Liying Huang, Yanzhong Chang, Pengxiu Cao, Akira Nakai, Ke Tan
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2021-08-01
Col·lecció:	Molecular Oncology
Matèries:	autophagy celastrol erastin mitochondrial fission mitophagy non‐small‐cell lung cancer
Accés en línia:	https://doi.org/10.1002/1878-0261.12936
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