A critical residue in the α1M2–M3 linker regulating mammalian GABAA receptor pore gating by diazepam

Benzodiazepines (BZDs) are a class of widely prescribed psychotropic drugs that modulate activity of GABAA receptors (GABAARs), neurotransmitter-gated ion channels critical for synaptic transmission. However, the physical basis of this modulation is poorly understood. We explore the role of an impor...

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Үндсэн зохиолчид:	Joseph W Nors, Shipra Gupta, Marcel P Goldschen-Ohm
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	eLife Sciences Publications Ltd 2021-02-01
Цуврал:	eLife
Нөхцлүүд:	benzodiazepine diazepam GABAA receptor M2-M3 linker allosteric modulator
Онлайн хандалт:	https://elifesciences.org/articles/64400
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!