Zolpidem Activation of Alpha 1-Containing GABAA Receptors Selectively Inhibits High Frequency Action Potential Firing of Cortical Neurons

Introduction: High frequency neuronal activity in the cerebral cortex can be induced by noxious stimulation during surgery, brain injury or poisoning. In this scenario, it is essential to block cortical hyperactivity to protect the brain against damage, e.g., by using drugs that act as positive allo...

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Autors principals:	Elena Neumann, Uwe Rudolph, Daniel E. Knutson, Guanguan Li, James M. Cook, Harald Hentschke, Bernd Antkowiak, Berthold Drexler
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2019-01-01
Col·lecció:	Frontiers in Pharmacology
Matèries:	zolpidem benzodiazepines GABAA receptor subtypes neocortex electrophysiology GABAA receptor subtype specific drugs
Accés en línia:	https://www.frontiersin.org/article/10.3389/fphar.2018.01523/full
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