Kidney-specific WNK1 amplifies kidney tubule responsiveness to potassium via WNK body condensates

To maintain potassium homeostasis, the kidney’s distal convoluted tubule (DCT) evolved to convert small changes in blood [K+] into robust effects on salt reabsorption. This process requires NaCl cotransporter (NCC) activation by the with-no-lysine (WNK) kinases. During hypokalemia, the kidney-specif...

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Principais autores:	Cary R. Boyd-Shiwarski, Rebecca T. Beacham, Jared A. Lashway, Katherine E. Querry, Shawn E. Griffiths, Daniel J. Shiwarski, Sophia A. Knoell, Nga H. Nguyen, Lubika J. Nkashama, Melissa N. Valladares, Anagha Bandaru, Allison L. Marciszyn, Jonathan Franks, Mara Sullivan, Simon C. Watkins, Aylin R. Rodan, Chou-Long Huang, Sean D. Stocker, Ossama B. Kashlan, Arohan R. Subramanya
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Clinical Investigation 2025-08-01
Series:	The Journal of Clinical Investigation
Assuntos:	Cell biology Nephrology
Acceso en liña:	https://doi.org/10.1172/JCI188792
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