Kidney-specific WNK1 amplifies kidney tubule responsiveness to potassium via WNK body condensates

To maintain potassium homeostasis, the kidney’s distal convoluted tubule (DCT) evolved to convert small changes in blood [K+] into robust effects on salt reabsorption. This process requires NaCl cotransporter (NCC) activation by the with-no-lysine (WNK) kinases. During hypokalemia, the kidney-specif...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Cary R. Boyd-Shiwarski, Rebecca T. Beacham, Jared A. Lashway, Katherine E. Querry, Shawn E. Griffiths, Daniel J. Shiwarski, Sophia A. Knoell, Nga H. Nguyen, Lubika J. Nkashama, Melissa N. Valladares, Anagha Bandaru, Allison L. Marciszyn, Jonathan Franks, Mara Sullivan, Simon C. Watkins, Aylin R. Rodan, Chou-Long Huang, Sean D. Stocker, Ossama B. Kashlan, Arohan R. Subramanya
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Clinical Investigation 2025-08-01
Edice:	The Journal of Clinical Investigation
Témata:	Cell biology Nephrology
On-line přístup:	https://doi.org/10.1172/JCI188792
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!