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5-Hydroxyindole-Based EZH2 Inhibitors Assembled via TCCA-Catalyzed Condensation and Nenitzescu Reactions

5-Hydroxyindole derivatives have various demonstrated biological activities. Herein, we used 5-hydroxyindole as a synthetic starting point for structural alterations in a combinatorial process to synthesize 22 different compounds with EZH2 inhibitor pharmacophores. A series of 5-hydroxyindole-derive...

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Principais autores: Fangyu Du, Qifan Zhou, Wenjiao Sun, Cheng Yang, Chunfu Wu, Lihui Wang, Guoliang Chen
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2020-04-01
סדרה:Molecules
נושאים:
5-hydroxyindole
EZH2 inhibitors
anti-tumor
trichloroisocyanuric acid
גישה מקוונת:https://www.mdpi.com/1420-3049/25/9/2059
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