5-Hydroxyindole-Based EZH2 Inhibitors Assembled via TCCA-Catalyzed Condensation and Nenitzescu Reactions

5-Hydroxyindole derivatives have various demonstrated biological activities. Herein, we used 5-hydroxyindole as a synthetic starting point for structural alterations in a combinatorial process to synthesize 22 different compounds with EZH2 inhibitor pharmacophores. A series of 5-hydroxyindole-derive...

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Bibliografische Detailangaben

Hauptverfasser:	Fangyu Du, Qifan Zhou, Wenjiao Sun, Cheng Yang, Chunfu Wu, Lihui Wang, Guoliang Chen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2020-04-01
Schriftenreihe:	Molecules
Schlagworte:	5-hydroxyindole EZH2 inhibitors anti-tumor trichloroisocyanuric acid
Online-Zugang:	https://www.mdpi.com/1420-3049/25/9/2059
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