The importance of FcRn in neuro-immunotherapies: From IgG catabolism, gene polymorphisms, IVIg dosing and efficiency to specific FcRn inhibitors
The neonatal Fc receptor (FcRn) binds endogenous IgG and protects it from lysosomal degradation by transporting it back to the cell surface to re-enter the circulation, extending the serum IgG life span. FcRn plays a role in the function of IVIg because the supraphysiological IgG levels derived from...
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| Principais autores: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
SAGE Publishing
2021-02-01
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| 叢編: | Therapeutic Advances in Neurological Disorders |
| 在線閱讀: | https://doi.org/10.1177/1756286421997381 |
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