Integrative structural insights into the IgG-FcRn interactions revealed by engineered FcRn-immobilized affinity chromatography
Abstract Molecular interactions between therapeutic antibodies and neonatal Fc receptor (FcRn) are major contributors to the long serum half-life of antibodies. Therefore, the in vitro affinity of IgG for FcRn is an important indicator of in vivo pharmacokinetic properties. However, the molecular ba...
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| Principais autores: | , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Portfolio
2026-03-01
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| Serier: | Communications Biology |
| Online adgang: | https://doi.org/10.1038/s42003-026-09789-3 |
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