Integrative structural insights into the IgG-FcRn interactions revealed by engineered FcRn-immobilized affinity chromatography

Abstract Molecular interactions between therapeutic antibodies and neonatal Fc receptor (FcRn) are major contributors to the long serum half-life of antibodies. Therefore, the in vitro affinity of IgG for FcRn is an important indicator of in vivo pharmacokinetic properties. However, the molecular ba...

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Principais autores:	Masato Kiyoshi, Takuo Suzuki, Naruaki Inoue, Ryoko Otake, Tatsuya Yumoto, Linko Hirono, Yosuke Terao, Hiroko Shibata, Teruhiko Ide, Satoru Nagatoishi, Kouhei Tsumoto, Akiko Ishii-Watabe
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2026-03-01
Serija:	Communications Biology
Online dostop:	https://doi.org/10.1038/s42003-026-09789-3
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