Melatonin alleviates diarrhea and visceral hypersensitivity in rats with diarrhea-predominant irritable bowel syndrome by modulating of the TLR4/MyD88/NF-κB pathway

Abstract Background This study aimed to investigate the effects of melatonin on diarrhea and visceral hypersensitivity in rats with diarrhea-predominant irritable bowel syndrome (IBS-D) and to explore its potential mechanisms through modulation of the TLR4/MyD88/NF-κB pathway. Methods Adult male Spr...

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Principais autores:	Zuohui Yuan, Xiaoping Yang, Xiaochun Wang, Xinlong Shi, Jia Chen, Lijun Huang, Jie Yang, Yuping Shi, Liping Zhang, Ping Mai
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2025-10-01
Series:	BMC Gastroenterology
Assuntos:	Diarrhea-predominant irritable bowel syndrome Melatonin TLR4/MyD88/NF-κB Intestinal microbiota
Acceso en liña:	https://doi.org/10.1186/s12876-025-04203-4
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