Melatonin alleviates diarrhea and visceral hypersensitivity in rats with diarrhea-predominant irritable bowel syndrome by modulating of the TLR4/MyD88/NF-κB pathway

Abstract Background This study aimed to investigate the effects of melatonin on diarrhea and visceral hypersensitivity in rats with diarrhea-predominant irritable bowel syndrome (IBS-D) and to explore its potential mechanisms through modulation of the TLR4/MyD88/NF-κB pathway. Methods Adult male Spr...

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Bibliografiska uppgifter

Huvudupphov:	Zuohui Yuan, Xiaoping Yang, Xiaochun Wang, Xinlong Shi, Jia Chen, Lijun Huang, Jie Yang, Yuping Shi, Liping Zhang, Ping Mai
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	BMC 2025-10-01
Serie:	BMC Gastroenterology
Ämnen:	Diarrhea-predominant irritable bowel syndrome Melatonin TLR4/MyD88/NF-κB Intestinal microbiota
Länkar:	https://doi.org/10.1186/s12876-025-04203-4
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