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Chronic hypoxia is associated with transcriptomic reprogramming and increased genomic instability in cancer cells

Hypoxia afflicts the microenvironment of solid tumors fueling malignancy. We investigated the impact of long hypoxia exposure on transcriptional remodeling, tumor mutational burden (TMB), and genomic instability of cancer cells that were grouped based on their inherent sensitivity or resistance to h...

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Autori principali: Raefa Abou Khouzam, Mohak Sharda, Shyama Prasad Rao, Stephanie Maame Kyerewah-Kersi, Nagwa Ahmed Zeinelabdin, Ayda Shah Mahmood, Husam Nawafleh, Munazza Samar Khan, Goutham Hassan Venkatesh, Salem Chouaib
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2023-03-01
Serie:Frontiers in Cell and Developmental Biology
Soggetti:
hypoxia
tumor mutational burden
solid tumors
transcriptome remodeling
genomic instability
chronic hypoxia
Accesso online:https://www.frontiersin.org/articles/10.3389/fcell.2023.1095419/full
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