Chronic hypoxia is associated with transcriptomic reprogramming and increased genomic instability in cancer cells

Hypoxia afflicts the microenvironment of solid tumors fueling malignancy. We investigated the impact of long hypoxia exposure on transcriptional remodeling, tumor mutational burden (TMB), and genomic instability of cancer cells that were grouped based on their inherent sensitivity or resistance to h...

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Manylion Llyfryddiaeth

Prif Awduron:	Raefa Abou Khouzam, Mohak Sharda, Shyama Prasad Rao, Stephanie Maame Kyerewah-Kersi, Nagwa Ahmed Zeinelabdin, Ayda Shah Mahmood, Husam Nawafleh, Munazza Samar Khan, Goutham Hassan Venkatesh, Salem Chouaib
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Frontiers Media S.A. 2023-03-01
Cyfres:	Frontiers in Cell and Developmental Biology
Pynciau:	hypoxia tumor mutational burden solid tumors transcriptome remodeling genomic instability chronic hypoxia
Mynediad Ar-lein:	https://www.frontiersin.org/articles/10.3389/fcell.2023.1095419/full
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!