Functional genomic analysis delineates regulatory mechanisms of GWAS-identified bipolar disorder risk variants

Abstract Background Genome-wide association studies (GWASs) have identified multiple risk loci for bipolar disorder (BD). However, pinpointing functional (or causal) variants in the reported risk loci and elucidating their regulatory mechanisms remain challenging. Methods We first integrated chromat...

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Xehetasun bibliografikoak

Egile Nagusiak:	Rui Chen, Zhihui Yang, Jiewei Liu, Xin Cai, Yongxia Huo, Zhijun Zhang, Ming Li, Hong Chang, Xiong-Jian Luo
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	BMC 2022-05-01
Saila:	Genome Medicine
Gaiak:	Bipolar disorder Genome-wide association study (GWAS) Functional genomics Transcription factor–disrupting SNPs Expression quantitative trait loci (eQTL) Regulatory mechanisms
Sarrera elektronikoa:	https://doi.org/10.1186/s13073-022-01057-3
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