Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants
IL-1 receptor-activated kinase 1 (IRAK1) is involved in signal transduction downstream of many TLRs and the IL-1R. Its potential as a drug target for chronic inflammatory diseases is underappreciated. To study its functional role in joint inflammation, we generated a mouse model expressing a functio...
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| Główni autorzy: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Clinical investigation
2022-07-01
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| Seria: | JCI Insight |
| Hasła przedmiotowe: | |
| Dostęp online: | https://doi.org/10.1172/jci.insight.149825 |
| Etykiety: |
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