Loss of Nonhematopoietic Osteopontin Weakens the Intestinal Barrier and Alters the Microbiome and Metabolome in Mice

Background and Aims: Inflammatory bowel disease (IBD) is characterized by intestinal barrier disruption and dysregulated interactions between host immunity and gut microbiota. Osteopontin (OPN) is considered a proinflammatory mediator in IBD, but nonhematopoietic cell-derived OPN may exert barrier-p...

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Κύριοι συγγραφείς:	Takehiro Hirano, Kohei Wagatsuma, Yuta Shimomori, Kotaro Akita, Tomoya Nakamura, Tsukasa Yamakawa, Yoshihiro Yokoyama, Hiroki Kurumi, Keisuke Ishigami, Kanna Nagaishi, Hiroshi Nakase
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Elsevier 2026-01-01
Σειρά:	Gastro Hep Advances
Θέματα:	Osteopontin Intestinal Barrier Gut Microbiota Interleukin-22 Inflammatory Bowel Disease
Διαθέσιμο Online:	http://www.sciencedirect.com/science/article/pii/S277257232600004X
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