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Ethyl pyruvate reduces organic dust-induced airway inflammation by targeting HMGB1-RAGE signaling

Abstract Background Animal production workers are persistently exposed to organic dust and can suffer from a variety of respiratory disease symptoms and annual decline in lung function. The role of high mobility group box-1 (HMGB1) in inflammatory airway diseases is emerging. Hence, we tested a hypo...

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Principais autores: Sanjana Mahadev Bhat, Nyzil Massey, Locke A. Karriker, Baljit Singh, Chandrashekhar Charavaryamath
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2019-02-01
Serier:Respiratory Research
Fag:
Organic dust
HMGB1
RAGE
Lung inflammation
Ethyl pyruvate
Online adgang:http://link.springer.com/article/10.1186/s12931-019-0992-3
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