Transient analysis and engineering of bacterial metabolic pathways using cell-penetrating peptide-peptide nucleic acid conjugates

Abstract Background Conventional genetic engineering approaches for bacterial metabolic pathway manipulation, although highly applicable, still face limitations including metabolic burden, irreversibility, and dependency on host cellular machinery. Cell-penetrating peptide-peptide nucleic acid conju...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Yugo Kawabuchi, Shunichi Kobayashi, Jaeyoung Yu, Gota Kasai, Miku Kobe, Rei Suo, Shiro Itoi, Koji Sode, Takahiro Muraoka, Ryutaro Asano, Tetsushi Mori
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-12-01
Schriftenreihe:	Microbial Cell Factories
Schlagworte:	Cell-penetrating peptides Peptide nucleic acid Metabolic engineering D-lactate dehydrogenase Glyoxalase II Synechocystis
Online-Zugang:	https://doi.org/10.1186/s12934-025-02909-4
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!