A distinct profile of tryptophan metabolism along the kynurenine pathway downstream of Toll-like receptor activation in irritable bowel syndrome

Irritable bowel syndrome (IBS), a disorder of the brain-gut axis, is characterised by the absence of reliable biological markers. Tryptophan is an essential amino acid that serves as a precursor to serotonin but which can alternatively be metabolised along the kynurenine pathway leading to the produ...

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Principais autores:	Gerard eClarke, Declan P McKernan, Gabor eGaszner, Eamonn M Quigley, John F Cryan, Timothy G Dinan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2012-05-01
coleção:	Frontiers in Pharmacology
Assuntos:	Irritable Bowel Syndrome Kynurenine Tryptophan IDO Toll-like receptor Whole-blood stimulation
Acesso em linha:	http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00090/full
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