Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks.
Hexavalent chromium [Cr(VI)] damages DNA and causes cancer, but it is unclear which DNA damage responses (DDRs) most critically protect cells from chromate toxicity. Here, genome-wide quantitative functional profiling, DDR measurements and genetic interaction assays in Schizosaccharomyces pombe reve...
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| Principais autores: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science (PLoS)
2018-08-01
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| Serier: | PLoS Genetics |
| Online adgang: | https://doi.org/10.1371/journal.pgen.1007595 |
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